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Naca (BC099375) Mouse Recombinant Protein

CAT: 0882-PM48207M5Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0882-PM48207M5Size:20 µg
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Background
Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER) . Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity) . Isoform 1 and isoform 2 appear to bind DNA and play roles in transcription. Isoform 1 may function as a specific coactivator for JUN, acting to stabilize the interaction of JUN homodimers with promoter elements.[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse nascent polypeptide-associated complex alpha polypeptide (cDNA clone MGC:117501 IMAGE:30525972), complete, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
SkNAC, mKIAA0363
Gene ID
17938
UniProt
Q60817
Accession Number mRNA
BC099375
Chromosomal Location
10 D3
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
23.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Naca
Species
Mouse
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/17938
Uniprot URL
https://www.uniprot.org/uniprot/Q60817
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/BC099375

UniProtKB · Q60817

Nascent polypeptide-associated complex subunit alpha

NACA_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
Q60817
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Naca
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q3THR6, Q4FZL8
Protein keywords

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Molecular function

ChaperoneDNA-binding

Cellular component

CytoplasmNucleus

Biological process

Protein transportTranscriptionTransport

Technical term

Reference proteome

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