Cbr1 (NM_007620) Mouse Recombinant Protein

• Background:

  NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  AW261796; Cbr; CR

• Gene ID:

  12408

• UniProt:

  P48758, B2RXY7

• Accession Number mRNA:

  NM_007620

• Chromosomal Location:

  16 54.53 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  30.6 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Cbr1

• Species:

  Mouse

• Protein ID:

  NP_031646

• Overview:

  Purified recombinant protein of Mouse carbonyl reductase 1 (Cbr1), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/12408

• Uniprot URL:

  https://www.uniprot.org/uniprot/P48758

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_007620

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_031646