Dscr3 (NM_007834) Mouse Recombinant Protein

• Background:

  Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1) . The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. In the endosomes, drives the retriever and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  AW538125; Dcra; Dscr3

• Gene ID:

  13185

• UniProt:

  O35075

• Accession Number mRNA:

  NM_007834

• Chromosomal Location:

  16 C4

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  33 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Vps26c

• Species:

  Mouse

• Protein ID:

  NP_031860

• Overview:

  Purified recombinant protein of Mouse VPS26 endosomal protein sorting factor C (Vps26c), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/13185

• Uniprot URL:

  https://www.uniprot.org/uniprot/O35075

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_007834

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_031860