Morf4l1 (NM_024431) Mouse Recombinant Protein

• Background:

  Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC) . Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  MKIAA4002; MORFRG15; MRG15; TEG-189; Tex189

• Gene ID:

  21761

• UniProt:

  P60762, Q569V4

• Accession Number mRNA:

  NM_024431

• Chromosomal Location:

  9 E3.1

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  37.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Morf4l1

• Species:

  Mouse

• Protein ID:

  NP_077751

• Overview:

  Purified recombinant protein of Mouse mortality factor 4 like 1 (Morf4l1), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/21761

• Uniprot URL:

  https://www.uniprot.org/uniprot/P60762

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_024431

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_077751