Ccnh (NM_023243) Mouse Recombinant Protein

• Background:

  Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  6330408H09Rik; AI661354; AV102684; AW538719

• Gene ID:

  66671

• UniProt:

  Q61458

• Accession Number mRNA:

  NM_023243

• Chromosomal Location:

  13 C3

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  37.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Ccnh

• Species:

  Mouse

• Protein ID:

  NP_075732

• Overview:

  Purified recombinant protein of Mouse cyclin H (Ccnh), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/66671

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q61458

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_023243

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_075732