Pim3 (NM_145478) Mouse Recombinant Protein

• Background:

  Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis and promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X (L), the regulation of cell cycle progression and protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  BC026639; Kid1

• Gene ID:

  223775

• UniProt:

  P58750, Q3TX64

• Accession Number mRNA:

  NM_145478

• Chromosomal Location:

  15 E3

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  36.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Pim3

• Species:

  Mouse

• Protein ID:

  NP_663453

• Overview:

  Purified recombinant protein of Mouse proviral integration site 3 (Pim3), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/223775

• Uniprot URL:

  https://www.uniprot.org/uniprot/P58750

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_145478

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_663453