Efnb2 (NM_010111) Mouse Recombinant Protein

• Background:

  Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  ELF-2; Epl5; Eplg5; Htk-L; LERK-5; Lerk5; NLERK-1

• Gene ID:

  13642

• UniProt:

  P52800, Q4FJM3

• Accession Number mRNA:

  NM_010111

• Chromosomal Location:

  8 3.42 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  37.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Efnb2

• Species:

  Mouse

• Protein ID:

  NP_034241

• Overview:

  Purified recombinant protein of Mouse ephrin B2 (Efnb2), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/13642

• Uniprot URL:

  https://www.uniprot.org/uniprot/P52800

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_010111

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_034241