Anxa1 (NM_010730) Mouse Recombinant Protein

• Background:

  Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:12475898) . Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (PubMed:12475898) . Promotes resolution of inflammation and wound healing (PubMed:25664854) . Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity) . Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17948261) . Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17948261) . Has no effect on unstimulated T-cells. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (By similarity) . Has high affinity for Ca (2+) and can bind up to eight Ca (2+) ions (By similarity) . Displays Ca (2+) -dependent binding to phospholipid membranes (By similarity) . Plays a role in the formation of phagocytic cups and phagosomes (PubMed:21245195) . Plays a role in phagocytosis by mediating the Ca (2+) -dependent interaction between phagosomes and the actin cytoskeleton (PubMed:21245195) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  Anx-1; Anx-A1; C430014K04Rik; Lpc-1; Lpc1

• Gene ID:

  16952

• UniProt:

  P10107, Q4FJV4

• Accession Number mRNA:

  NM_010730

• Chromosomal Location:

  19 13.83 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  38.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Anxa1

• Species:

  Mouse

• Protein ID:

  NP_034860

• Overview:

  Purified recombinant protein of Mouse annexin A1 (Anxa1), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/16952

• Uniprot URL:

  https://www.uniprot.org/uniprot/P10107

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_010730

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_034860