Homer3 (NM_011984) Mouse Recombinant Protein

• Background:

  Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (By similarity) . Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  AW146114

• Gene ID:

  26558

• UniProt:

  Q99JP6

• Accession Number mRNA:

  NM_011984

• Chromosomal Location:

  8 B3.3

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  39.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Homer3

• Species:

  Mouse

• Protein ID:

  NP_036114

• Overview:

  Purified recombinant protein of Mouse homer scaffolding protein 3 (Homer3), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/26558

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q99JP6

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_011984

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_036114