Psmc3 (NM_008948) Mouse Recombinant Protein

• Background:

  Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  TBP-1

• Gene ID:

  19182

• UniProt:

  O88685, Q3TKG4

• Accession Number mRNA:

  NM_008948

• Chromosomal Location:

  2 50.44 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  49.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Psmc3

• Species:

  Mouse

• Protein ID:

  NP_032974

• Overview:

  Purified recombinant protein of Mouse proteasome (prosome, macropain) 26S subunit, ATPase 3 (Psmc3), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/19182

• Uniprot URL:

  https://www.uniprot.org/uniprot/O88685

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_008948

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_032974