Esrp1 (NM_194055) Mouse Recombinant Protein

• Background:

  MRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT) . Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity) . Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium (PubMed:29107558) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  2210008M09Rik; A630065D16; BC031468; Rbm35a

• Gene ID:

  207920

• UniProt:

  Q3US41, F8WGU3

• Accession Number mRNA:

  NM_194055

• Chromosomal Location:

  4 A1

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  49.6 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Esrp1

• Species:

  Mouse

• Protein ID:

  NP_918944

• Overview:

  Purified recombinant protein of Mouse epithelial splicing regulatory protein 1 (Esrp1), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/207920

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q3US41

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_194055

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_918944