Sox10 (BC018551) Mouse Recombinant Protein

• Background:

  Transcription factor that plays a central role in developing and mature glia (PubMed:24204311, PubMed:27532821) . Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (PubMed:24204311, PubMed:27532821) . Once induced, MYRF cooperates with SOX10 to implement the myelination program (PubMed:24204311) . Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  Dom; gt; Sox21

• Gene ID:

  20665

• UniProt:

  Q04888

• Accession Number mRNA:

  BC018551

• Chromosomal Location:

  15 37.7 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  49.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Sox10

• Species:

  Mouse

• Overview:

  Purified recombinant protein of Mouse SRY-box containing gene 10 (cDNA clone MGC:18351 IMAGE:3675437), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/20665

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q04888

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/BC018551