Frmd8 (NM_026169) Mouse Recombinant Protein

• Background:

  Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway (PubMed:29897333) . By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (By similarity) . Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  1200004M23Rik; 2310035N23Rik; 4931429L16Rik; AU018809

• Gene ID:

  67457

• UniProt:

  Q3UFK8

• Accession Number mRNA:

  NM_026169

• Chromosomal Location:

  19 A

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  51.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Frmd8

• Species:

  Mouse

• Protein ID:

  NP_080445

• Overview:

  Purified recombinant protein of Mouse FERM domain containing 8 (Frmd8), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/67457

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q3UFK8

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_026169

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_080445