Mef2a (BC096598) Mouse Recombinant Protein

• Background:

  Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT] (4) TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  A430079H05Rik

• Gene ID:

  17258

• UniProt:

  Q60929

• Accession Number mRNA:

  BC096598

• Chromosomal Location:

  7 36.72 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  53 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Mef2a

• Species:

  Mouse

• Overview:

  Purified recombinant protein of Mouse myocyte enhancer factor 2A (cDNA clone MGC:106070 IMAGE:4979487), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/17258

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q60929

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/BC096598