Cyp2s1 (NM_028775) Mouse Recombinant Protein

• Background:

  A cytochrome P450 monooxygenase involved in the metabolism of retinoids and eicosanoids. In epidermis, may contribute to the oxidative metabolism of all-trans-retinoic acid. For this activity, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) . Additionally, displays peroxidase and isomerase activities toward various oxygenated eicosanoids such as prostaglandin H2 (PGH2) and hydroperoxyeicosatetraenoates (HPETEs) . Independently of cytochrome P450 reductase, NADPH, and O2, catalyzes the breakdown of PGH2 to hydroxyheptadecatrienoic acid (HHT) and malondialdehyde (MDA), which is known to act as a mediator of DNA damage.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  1200011C15Rik; AU041727; C79779

• Gene ID:

  74134

• UniProt:

  Q9DBX6

• Accession Number mRNA:

  NM_028775

• Chromosomal Location:

  7 A3

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  55.6 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Cyp2s1

• Species:

  Mouse

• Protein ID:

  NP_083051

• Overview:

  Purified recombinant protein of Mouse cytochrome P450, family 2, subfamily s, polypeptide 1 (Cyp2s1), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/74134

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9DBX6

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_028775

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_083051