Cdk5rap3 (NM_030248) Mouse Recombinant Protein

• Background:

  Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation. Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation. Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint. Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation. May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress. May also play a role in the rupture of the nuclear envelope during apoptosis. May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  1810007E24Rik; BC002318; C53; C81486; HSF-27; IC53; LZAP; MST016

• Gene ID:

  80280

• UniProt:

  Q99LM2

• Accession Number mRNA:

  NM_030248

• Chromosomal Location:

  11 D

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  57 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Cdk5rap3

• Species:

  Mouse

• Protein ID:

  NP_084524

• Overview:

  Purified recombinant protein of Mouse CDK5 regulatory subunit associated protein 3 (Cdk5rap3), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/80280

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q99LM2

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_030248

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_084524