Trip10 (NM_134125) Mouse Recombinant Protein

• Background:

  Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL (By similarity) . Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  AI646975; Cip4

• Gene ID:

  106628

• UniProt:

  Q8CJ53

• Accession Number mRNA:

  NM_134125

• Chromosomal Location:

  17 D

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  62.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Trip10

• Species:

  Mouse

• Protein ID:

  NP_598886

• Overview:

  Purified recombinant protein of Mouse thyroid hormone receptor interactor 10 (Trip10), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/106628

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q8CJ53

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_134125

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_598886