Plat (NM_008872) Mouse Recombinant Protein

• Background:

  This gene encodes a key enzyme of the fibrinolytic pathway. The encoded protein undergoes proteolytic processing by plasmin to generate a heterodimeric serine protease that cleaves the proenzyme plasminogen to produce plasmin, a protease that is required to break down fibrin clots. Additionally, the encoded protein is involved in other biological processes such as synaptic plasticity, cell migration and tissue remodeling. Mice lacking the encoded protein display a reduction in long-term potentiation in hippocampus and conversely, transgenic mice overexpressing the encoded protein have increased and prolonged long-term potentiation. [provided by RefSeq, Jul 2015]

• Synonyms:

  AU020998; AW212668; D8Ertd2; D8Ertd2e; t; t-; tPA

• Gene ID:

  18791

• UniProt:

  P11214

• Accession Number mRNA:

  NM_008872

• Chromosomal Location:

  8 11.42 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  63.1 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Plat

• Species:

  Mouse

• Protein ID:

  NP_032898

• Overview:

  Purified recombinant protein of Mouse plasminogen activator, tissue (Plat), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/18791

• Uniprot URL:

  https://www.uniprot.org/uniprot/P11214

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_008872

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_032898