Trim29 (NM_023655) Mouse Recombinant Protein

• Background:

  Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of TMEM173/STING in a similar way, leading to its degradation.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  1110047J21Rik; 2810431N19Rik; 4732461M22Rik; AI119726

• Gene ID:

  72169

• UniProt:

  Q8R2Q0

• Accession Number mRNA:

  NM_023655

• Chromosomal Location:

  9 A5.1

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  65.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Trim29

• Species:

  Mouse

• Protein ID:

  NP_076144

• Overview:

  Purified recombinant protein of Mouse tripartite motif-containing 29 (Trim29), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/72169

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q8R2Q0

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_023655

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_076144