Umod (NM_009470) Mouse Recombinant Protein

• Background:

  This gene encodes a glycoprotein that is the most abundant protein in mammalian urine under physiological conditions. It is synthesized in the kidney as a glycosyl-phosphatidylinositol anchored protein and released into urine as a soluble form by proteolytic cleavage. It is thought to regulate water and salt balance in the thick ascending limb of Henle and to protect against urinary tract infection and calcium oxalate crystal formation. In mouse deficiency of this gene is associated with increased susceptibility to bacterial infections and formation of calcium crystals in kidneys. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

• Synonyms:

  THP; ureh; Urehd; Urehd1; urehr4; uromu

• Gene ID:

  22242

• UniProt:

  Q91X17

• Accession Number mRNA:

  NM_009470

• Chromosomal Location:

  7 63.88 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  70.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Umod

• Species:

  Mouse

• Protein ID:

  NP_033496

• Overview:

  Purified recombinant protein of Mouse uromodulin (Umod), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/22242

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q91X17

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_009470

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_033496