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Picalm (BC011470) Mouse Recombinant Protein

CAT: 0882-PM45359M5Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0882-PM45359M5Size:20 µg
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Background
Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly. Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8. In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors. Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) .[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse phosphatidylinositol binding clathrin assembly protein (cDNA clone MGC:19382 IMAGE:2651109), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
MGC19382, CALM, CLTH, MGC36413, MGC36616, PAP180, mKIAA4114
Gene ID
233489
UniProt
Q7M6Y3
Accession Number mRNA
BC011470
Chromosomal Location
7 50.47 cM
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
123.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Picalm
Species
Mouse
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/233489
Uniprot URL
https://www.uniprot.org/uniprot/Q7M6Y3
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/BC011470

UniProtKB · Q7M6Y3

Phosphatidylinositol-binding clathrin assembly protein

PICAL_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
Q7M6Y3
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Picalm
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q3TS04, Q811P1, Q8BUF6, Q8CIH8, Q8R0A9, Q8R3E1, Q8VDN5, Q921L0
Protein keywords

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneCoated pitCytoplasmic vesicleGolgi apparatusMembraneNucleus

Molecular function

Developmental protein

Biological process

Endocytosis

Technical term

Reference proteome

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