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BC002230 (BC025577) Mouse Recombinant Protein

CAT: 0882-PM45263M5Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0882-PM45263M5Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation. Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation. Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome. By preventing the degradation of RNAs in the nucleus, it promotes their export to the cytoplasm.[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse cDNA sequence BC002230 (cDNA clone MGC:38228 IMAGE:5323598), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
6720454P05Rik
Gene ID
217827
UniProt
Q80XC6
Accession Number mRNA
BC025577
Chromosomal Location
12 E
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
86.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
BC002230
Species
Mouse
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/217827
Uniprot URL
https://www.uniprot.org/uniprot/Q80XC6
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/BC025577

UniProtKB · Q80XC6

Nuclear exosome regulator NRDE2

NRDE2_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
Q80XC6
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Nrde2
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
—
Processing
—
Secondary accessions
E9QKV8, Q8R3D7, Q99LT9
Protein keywords

PTM

Acetylation

Biological process

Cell cycleCell divisionDNA damageMitosismRNA processingmRNA splicing

Domain

Coiled coilRepeat

Cellular component

Nucleus

Technical term

Reference proteome

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