Ssrp1 (BC042502) Mouse Recombinant Protein

• Background:

  Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II) . Binds specifically to double-stranded DNA. Also acts as a transcriptional coactivator for p63/TP63.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  C81323; Hmg1-rs1; Hmgi-rs3; Hmgox; T160

• Gene ID:

  20833

• UniProt:

  Q08943

• Accession Number mRNA:

  BC042502

• Chromosomal Location:

  2 49.45 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  102.3 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Ssrp1

• Species:

  Mouse

• Overview:

  Purified recombinant protein of Mouse structure specific recognition protein 1 (cDNA clone MGC:30412 IMAGE:5005209), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/20833

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q08943

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/BC042502