Smarcad1 (BC042442) Mouse Recombinant Protein

• Background:

  DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  AV081750; AW226546; D6Pas1; Etl1; mKIAA1122

• Gene ID:

  13990

• UniProt:

  Q04692

• Accession Number mRNA:

  BC042442

• Chromosomal Location:

  6 30.11 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  153.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Smarcad1

• Species:

  Mouse

• Overview:

  Purified recombinant protein of Mouse SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1`, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/13990

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q04692

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/BC042442