Lrp6 (NM_008514) Mouse Recombinant Protein

• Background:

  Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  ; skax26

• Gene ID:

  16974

• UniProt:

  O88572, A0A0R4J0A9

• Accession Number mRNA:

  NM_008514

• Chromosomal Location:

  6 65.37 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  180.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Lrp6

• Species:

  Mouse

• Protein ID:

  NP_032540

• Overview:

  Purified recombinant protein of Mouse low density lipoprotein receptor-related protein 6 (Lrp6), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/16974

• Uniprot URL:

  https://www.uniprot.org/uniprot/O88572

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_008514

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_032540