Ptpa (NM_138748) Mouse Recombinant Protein

• Background:

  PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A (i) ) in presence of ATP and Mg (2+) . Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A (D) in presence of ATP and Mg (2+) (in vitro) . The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A (D) :PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  2610042B21Rik; C77440; N28142; Ppp2r4; PR53

• Gene ID:

  110854

• UniProt:

  P58389, Q543N6

• Accession Number mRNA:

  NM_138748

• Chromosomal Location:

  2 21.71 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  37.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Ptpa

• Species:

  Mouse

• Protein ID:

  NP_620087

• Overview:

  Purified recombinant protein of Mouse protein phosphatase 2 protein activator (Ptpa), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/110854

• Uniprot URL:

  https://www.uniprot.org/uniprot/P58389

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_138748

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_620087