Snx9 (NM_025664) Mouse Recombinant Protein

• Background:

  Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton (PubMed:23437151) . Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  2700073N08Rik; SDP1; SH3PX1

• Gene ID:

  66616

• UniProt:

  Q91VH2, Q3U1P2

• Accession Number mRNA:

  NM_025664

• Chromosomal Location:

  17 3.51 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  66.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Snx9

• Species:

  Mouse

• Protein ID:

  NP_079940

• Overview:

  Purified recombinant protein of Mouse sorting nexin 9 (Snx9), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/66616

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q91VH2

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_025664

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_079940