Lgmn (NM_011175) Mouse Recombinant Protein

• Background:

  This gene encodes a member of the cysteine peptidase family C13 that plays an important role in the endosome/lysosomal degradation system. The encoded inactive preproprotein undergoes autocatalytic removal of the C-terminal inhibitory propeptide to generate the active endopeptidase that cleaves protein substrates on the C-terminal side of asparagine residues. Mice lacking the encoded protein exhibit defects in the lysosomal processing of proteins resulting in their accumulation in the lysosomes, and develop symptoms resembling hemophagocytic lymphohistiocytosis. [provided by RefSeq, Aug 2016]

• Synonyms:

  A; AEP; AI746452; AU022324; Pr; Prsc1

• Gene ID:

  19141

• UniProt:

  O89017, A2RTI3, Q3UE99

• Accession Number mRNA:

  NM_011175

• Chromosomal Location:

  12 E

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  49.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Lgmn

• Species:

  Mouse

• Protein ID:

  NP_035305

• Overview:

  Purified recombinant protein of Mouse legumain (Lgmn), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/19141

• Uniprot URL:

  https://www.uniprot.org/uniprot/O89017

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_011175

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_035305