Mpp5 (NM_019579) Mouse Recombinant Protein

• Background:

  Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity) . Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (PubMed:17182851, PubMed:20237282) . Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (By similarity) . Required during embryonic and postnatal retinal development (PubMed:22398208) . Required for the maintenance of cerebellar progenitor cells in an undifferentiated proliferative state, preventing premature differentiation, and is required for cerebellar histogenesis, fissure formation and cerebellar layer organization (PubMed:26657772) . Plays a role in the radial and longitudinal extension of the myelin sheath in Schwann cells (PubMed:20237282) . May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter (PubMed:15234345) . May play a role in the T-cell receptor-mediated activation of NF-kappa-B (By similarity) . Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (PubMed:15677456) . Required for the normal polarized localization of the vesicular marker STX4 (PubMed:20237282) . Required for the correct trafficking of the myelin proteins PMP22 and MAG (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  3830420B02Rik; AI255216; AI644496; Pals1

• Gene ID:

  56217

• UniProt:

  Q9JLB2, B2RRY4

• Accession Number mRNA:

  NM_019579

• Chromosomal Location:

  12 C3

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  77.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Mpp5

• Species:

  Mouse

• Protein ID:

  NP_062525

• Overview:

  Purified recombinant protein of Mouse membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) (Mpp5), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/56217

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9JLB2

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_019579

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_062525