Ift57 (NM_028680) Mouse Recombinant Protein

• Background:

  Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  4833420A15Rik; Esrrbl1; Hippi; MHS4R2

• Gene ID:

  73916

• UniProt:

  Q8BXG3, B2RQZ0

• Accession Number mRNA:

  NM_028680

• Chromosomal Location:

  16 B5

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  48.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Ift57

• Species:

  Mouse

• Protein ID:

  NP_082956

• Overview:

  Purified recombinant protein of Mouse intraflagellar transport 57 (Ift57), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/73916

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q8BXG3

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_028680

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_082956