Gldn (NM_177350) Mouse Recombinant Protein

• Background:

  Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between Schwann cell microvilli and axons via its interactions with NRCAM and NFASC (PubMed:20188654) . Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters (PubMed:20188654) . Required, together with NRCAM, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier (PubMed:24719088) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  Clom; Colm; CRG-L2; Crgl2; Crlg2

• Gene ID:

  235379

• UniProt:

  Q8BMF8

• Accession Number mRNA:

  NM_177350

• Chromosomal Location:

  9 A5.3

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  59.6 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Gldn

• Species:

  Mouse

• Protein ID:

  NP_796324

• Overview:

  Purified recombinant protein of Mouse gliomedin (Gldn), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/235379

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q8BMF8

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_177350

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_796324