Elf3 (NM_007921) Mouse Recombinant Protein

• Background:

  Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter (By similarity) . Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity (By similarity) . Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway (By similarity) . May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  ESE-1; ESX; jen

• Gene ID:

  13710

• UniProt:

  Q3UPW2

• Accession Number mRNA:

  NM_007921

• Chromosomal Location:

  1 E4

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  42.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Elf3

• Species:

  Mouse

• Protein ID:

  NP_031947

• Overview:

  Purified recombinant protein of Mouse E74-like factor 3 (Elf3), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/13710

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q3UPW2

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_007921

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_031947