Cd22 (NM_001043317) Mouse Recombinant Protein

• Background:

  Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  A530093D23; Lyb-8; Lyb8

• Gene ID:

  12483

• UniProt:

  P35329, Q3UP36

• Accession Number mRNA:

  NM_001043317

• Chromosomal Location:

  7 19.26 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  97.6 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Cd22

• Species:

  Mouse

• Protein ID:

  NP_001036782

• Overview:

  Purified recombinant protein of Mouse CD22 antigen (Cd22), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/12483

• Uniprot URL:

  https://www.uniprot.org/uniprot/P35329

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001043317

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001036782