Socs1 (NM_009896) Mouse Recombinant Protein

• Background:

  SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity (By similarity) . Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF) . Regulates interferon-gamma mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2 (By similarity) . SOCS1 appears to be a negative regulator in IGF1R signaling pathway (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  Cish1; Cish7; JAB; SOCS-1; SSI-1

• Gene ID:

  12703

• UniProt:

  O35716

• Accession Number mRNA:

  NM_009896

• Chromosomal Location:

  16 5.81 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  23.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Socs1

• Species:

  Mouse

• Protein ID:

  NP_034026

• Overview:

  Purified recombinant protein of Mouse suppressor of cytokine signaling 1 (Socs1), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/12703

• Uniprot URL:

  https://www.uniprot.org/uniprot/O35716

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_009896

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_034026