Eps15 (NM_001159964) Mouse Recombinant Protein

• Background:

  Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs) . Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR) ; internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  2410112D09Rik

• Gene ID:

  13858

• UniProt:

  P42567, Q80ZL3, A0A0R4J0A0

• Accession Number mRNA:

  NM_001159964

• Chromosomal Location:

  4 C7

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  64.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Eps15

• Species:

  Mouse

• Protein ID:

  NP_001153436

• Overview:

  Purified recombinant protein of Mouse epidermal growth factor receptor pathway substrate 15 (Eps15), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/13858

• Uniprot URL:

  https://www.uniprot.org/uniprot/P42567

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001159964

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001153436