Stat3 (NM_213659) Mouse Recombinant Protein

• Background:

  The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]

• Synonyms:

  1110034C02Rik; A; Aprf; AW109958

• Gene ID:

  20848

• UniProt:

  P42227, Q3ULI4

• Accession Number mRNA:

  NM_213659

• Chromosomal Location:

  11 63.82 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  88.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Stat3

• Species:

  Mouse

• Protein ID:

  NP_998824

• Overview:

  Purified recombinant protein of Mouse signal transducer and activator of transcription 3 (Stat3), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/20848

• Uniprot URL:

  https://www.uniprot.org/uniprot/P42227

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_213659

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_998824