Unc5c (NM_009472) Mouse Recombinant Protein

• Background:

  Receptor for netrin required for axon guidance (PubMed:22685302, PubMed:10399920) . Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (PubMed:10399920, PubMed:22685302) . NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977) . Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion (PubMed:10399920) . Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC (PubMed:22685302) . Also involved in corticospinal tract axon guidance independently of DCC (PubMed:9126743, PubMed:9389662, PubMed:12451134) . Involved in dorsal root ganglion axon projection towards the spinal cord (By similarity) . It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  B130051O18Rik; rcm; Unc5h3

• Gene ID:

  22253

• UniProt:

  O08747

• Accession Number mRNA:

  NM_009472

• Chromosomal Location:

  3 65.57 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  103.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Unc5c

• Species:

  Mouse

• Protein ID:

  NP_033498

• Overview:

  Purified recombinant protein of Mouse unc-5 netrin receptor C (Unc5c), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/22253

• Uniprot URL:

  https://www.uniprot.org/uniprot/O08747

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_009472

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_033498