Eph receptor B2 (EPHB2) (NM_017449) Human Recombinant Protein

• Background:

  This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]

• Synonyms:

  BDPLT22; CAPB; DRT; EK5; EPHT3; ERK; Hek5; PCBC; Tyro5

• Gene ID:

  2048

• UniProt:

  P29323, Q6NVW1, Q4LE53

• Accession Number mRNA:

  NM_017449

• Chromosomal Location:

  1p36.12

• Expression System:

  HEK293

• Tag:

  C-DDK/His

• Related Pathways:

  Axon guidance

• Field of Research:

  Axon guidance

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  PBS, pH7.4, 10% glycerol

• Function:

  Druggable Genome, Protein Kinase, Transmembrane

• Molecular Weight:

  61 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  EPHB2

• Species:

  Human

• Protein ID:

  NP_059145

• Overview:

  Purified recombinant protein of human EPH receptor B2 (EPHB2), transcript variant 1, with C-terminal DDK/His tag, expressed in human cells, 20 µg

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/2048

• Uniprot URL:

  https://www.uniprot.org/uniprot/P29323

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_017449

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_059145