LGR5 (NM_003667) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

• Synonyms:

  FEX; GPR49; GPR67; GRP49; HG38

• Gene ID:

  8549

• UniProt:

  O75473, A0A0A8K8C7

• Accession Number mRNA:

  NM_003667

• Chromosomal Location:

  12q21.1

• Expression System:

  HEK293

• Tag:

  C-Fc

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  PBS, pH7.4, 10% glycerol

• Function:

  Druggable Genome, GPCR, Transmembrane

• Molecular Weight:

  38 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  LGR5

• Species:

  Human

• Protein ID:

  NP_003658

• Overview:

  Purified recombinant protein of Homo sapiens leucine-rich repeat containing G protein-coupled receptor 5 (LGR5), residues 447-561aa, with C-terminal Fc tag, expressed in HEK293 cells.

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/8549

• Uniprot URL:

  https://www.uniprot.org/uniprot/O75473

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_003667

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_003658