PD-L1 (CD274) (NM_014143) Human Recombinant Protein

• Background:

  This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

• Synonyms:

  B7-H; B7H1; hPD-L1; PD-L1; PDCD1L1; PDCD1LG1; PDL1

• Gene ID:

  29126

• UniProt:

  Q9NZQ7

• Accession Number mRNA:

  NM_014143

• Chromosomal Location:

  9p24.1

• Expression System:

  HEK293

• Tag:

  C-Fc

• Related Pathways:

  Cell adhesion molecules (CAMs)

• Field of Research:

  Cell adhesion molecules (CAMs)

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  PBS, pH7.4, 10% glycerol

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  50

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CD274

• Species:

  Human

• Protein ID:

  NP_054862

• Overview:

  Purified recombinant protein of Homo sapiens programmed cell death 1 ligand 1 (PD-L1/CD274), residues 19-239aa, with C-terminal Fc tag, expressed in HEK293 cells.

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/29126

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9NZQ7

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_014143

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_054862