CTLA4 (NM_005214) Human Recombinant Protein

• Background:

  This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]

• Synonyms:

  ALPS5; CD; CD152; CELIAC3; CTLA-4; GRD4; GSE; IDDM12

• Gene ID:

  1493

• UniProt:

  P16410

• Accession Number mRNA:

  NM_005214

• Chromosomal Location:

  2q33.2

• Expression System:

  HEK293

• Tag:

  C-DDK/His

• Related Pathways:

  Autoimmune thyroid disease, Cell adhesion molecules (CAMs), T cell receptor signaling pathway

• Field of Research:

  Autoimmune thyroid disease, Cell adhesion molecules (CAMs), T cell receptor signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  PBS, pH7.4, 10% glycerol

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  16 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CTLA4

• Species:

  Human

• Protein ID:

  NP_005205

• Overview:

  Purified recombinant protein of Human cytotoxic T-lymphocyte-associated protein 4 (CTLA4), transcript variant 1, with C-terminal DDK/His tag, expressed in human cells

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/1493

• Uniprot URL:

  https://www.uniprot.org/uniprot/P16410

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_005214

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_005205