TIM 3 (HAVCR2) (NM_032782) Human Recombinant Protein

• Background:

  The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]

• Synonyms:

  CD366; HAVcr-2; KIM-3; SPTCL; Tim-3; TIM3; TIMD-3; TIMD3

• Gene ID:

  84868

• UniProt:

  Q8TDQ0

• Accession Number mRNA:

  NM_032782

• Chromosomal Location:

  5q33.3

• Expression System:

  HEK293

• Tag:

  C-Fc

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  PBS, pH7.4, 10% glycerol

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  45 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  HAVCR2

• Species:

  Human

• Protein ID:

  NP_116171

• Overview:

  Purified recombinant protein of human T-cell immunoglobulin mucin receptor 3 (TIM3), with C-terminal Fc tag, expressed in human cells, 20 µg

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/84868

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q8TDQ0

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_032782

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_116171