ATF2 (NM_001880) Human Recombinant Protein

• Background:

  This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014]

• Synonyms:

  CRE-BP1; CREB-2; CREB2; HB16; TREB7

• Gene ID:

  1386

• UniProt:

  P15336

• Accession Number mRNA:

  NM_001880

• Chromosomal Location:

  2q31.1

• Expression System:

  Sf9

• Tag:

  C-His

• Related Pathways:

  MAPK signaling pathway

• Field of Research:

  MAPK signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Activity:

  28298524

• Form:

  Liquid

• Buffer:

  50mM Tris-HCl pH8.0, 150mM NaCl, 20% glycerol

• Function:

  Druggable Genome, Transcription Factors

• Molecular Weight:

  55 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  ATF2

• Species:

  Human

• Protein ID:

  NP_001871

• Overview:

  Recombinant protein of human activating transcription factor 2 (ATF2), full length, with C-terminal polyhistidine tag, expressed in sf9 cells.

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/1386

• Uniprot URL:

  https://www.uniprot.org/uniprot/P15336

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001880

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001871