SRC (NM_005417) Human Recombinant Protein

• Background:

  This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

• Synonyms:

  ASV; c-SRC; p60-Src; SRC1; THC6

• Gene ID:

  6714

• UniProt:

  P12931

• Accession Number mRNA:

  NM_005417

• Chromosomal Location:

  20q11.23

• Expression System:

  Sf9

• Tag:

  C-His

• Related Pathways:

  Adherens junction, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Focal adhesion, Gap junction, GnRH signaling pathway, Tight junction, VEGF signaling pathway

• Field of Research:

  Adherens junction, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Focal adhesion, Gap junction, GnRH signaling pathway, Tight junction, VEGF signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  50mM Tris-HCl pH8.0, 150mM NaCl, 20% glycerol

• Function:

  Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Stem cell relevant signaling - JAK/STAT signaling pathway

• Molecular Weight:

  60 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  SRC

• Species:

  Human

• Protein ID:

  NP_005408

• Overview:

  Recombinant protein of human v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) (SRC), with C-terminal polyhistidine tag, expressed in sf9 cells.

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/6714

• Uniprot URL:

  https://www.uniprot.org/uniprot/P12931

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_005417

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_005408