Eph receptor A3 (EPHA3) (NM_005233) Human Recombinant Protein

• Background:

  This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]

• Synonyms:

  EK4; ETK; ETK1; HEK; HEK4; TYRO4

• Gene ID:

  2042

• UniProt:

  P29320, A0A140VJJ0, Q6P4R6

• Accession Number mRNA:

  NM_005233

• Chromosomal Location:

  3p11.1

• Expression System:

  Sf9

• Tag:

  C-DDK

• Related Pathways:

  Axon guidance

• Field of Research:

  Axon guidance

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol

• Function:

  Druggable Genome, Protein Kinase, Secreted Protein, Transmembrane

• Molecular Weight:

  58.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  EPHA3

• Species:

  Human

• Protein ID:

  NP_005224

• Overview:

  Recombinant protein of human EPH receptor A3 (EPHA3), transcript variant 1, residues 21-541aa, with C-terminal DDK tag, expressed in sf9, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/2042

• Uniprot URL:

  https://www.uniprot.org/uniprot/P29320

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_005233

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_005224