BAIAP2 (NM_017450) Human Recombinant Protein

• Background:

  The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1) -binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]

• Synonyms:

  BAP2; FLAF3; IRSP53; WAML

• Gene ID:

  10458

• UniProt:

  Q9UQB8

• Accession Number mRNA:

  NM_017450

• Chromosomal Location:

  17q25.3

• Expression System:

  Sf9

• Tag:

  C-DDK

• Related Pathways:

  Adherens junction, Regulation of actin cytoskeleton

• Field of Research:

  Adherens junction, Regulation of actin cytoskeleton

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  57.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  BAIAP2

• Species:

  Human

• Protein ID:

  NP_059344

• Overview:

  Recombinant protein of human BAI1-associated protein 2 (BAIAP2), transcript variant 1, full length, with C-terminal DDK tag, expressed in sf9 cells

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/10458

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9UQB8

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_017450

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_059344