GFRAL (NM_207410) Human Recombinant Protein

• Background:

  Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099) . Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  BA360D14.1; C6orf144; GRAL; UNQ9356

• Gene ID:

  389400

• UniProt:

  Q6UXV0

• Accession Number mRNA:

  NM_207410

• Chromosomal Location:

  6p12.1

• Expression System:

  Sf9

• Tag:

  C-His

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  50 mM Tris.HCl, pH 8.0, 150 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  37.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  GFRAL

• Species:

  Human

• Protein ID:

  NP_997293

• Overview:

  Purified recombinant protein of Human GDNF family receptor alpha like (GFRAL), with C-terminal His tag, secretory expressed in Sf9 cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/389400

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q6UXV0

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_207410

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_997293