SDF1 (CXCL12) (NM_000609) Human Recombinant Protein

• Background:

  This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

• Synonyms:

  IRH; PBSF; SCYB12; SDF1; TLSF; TPAR1

• Gene ID:

  6387

• UniProt:

  P48061

• Accession Number mRNA:

  NM_000609

• Chromosomal Location:

  10q11.21

• Expression System:

  E. coli

• Tag:

  Tag Free

• Related Pathways:

  Axon guidance, Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Leukocyte transendothelial migration

• Field of Research:

  Axon guidance, Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Leukocyte transendothelial migration

• Concentration:

  Resuspend the protein to the desired concentration in proper buffer.

• Endotoxin:

  < 0.1 EU per 1 µg of the protein by the LAL

• Purity:

  >95% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Lyophilized

• Buffer:

  Lyophilized from a sterile solution containing 20 mM phosphate buffer, pH7.4.

• Function:

  Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein

• Molecular Weight:

  8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CXCL12

• Species:

  Human

• Protein ID:

  NP_000600

• Overview:

  Recombinant protein of human stromal cell-derived factor-1 (SDF-1) produced in E. coli.

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/6387

• Uniprot URL:

  https://www.uniprot.org/uniprot/P48061

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000609

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000600