Alpha Synuclein (SNCA) (NM_000345) Human Recombinant Protein

• Background:

  Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]

• Synonyms:

  NACP; PARK1; PARK4; PD1

• Gene ID:

  6622

• UniProt:

  P37840

• Accession Number mRNA:

  NM_000345

• Chromosomal Location:

  4q22.1

• Expression System:

  E. coli

• Tag:

  Tag Free

• Related Pathways:

  Alzheimer's disease, Parkinson's disease

• Field of Research:

  Alzheimer's disease, Parkinson's disease

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 95% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  PBS, pH7.4

• Function:

  Druggable Genome

• Molecular Weight:

  14.3 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  SNCA

• Species:

  Human

• Protein ID:

  NP_000336

• Overview:

  Purified recombinant protein of Human synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 1, full length, Tag free, expressed in E. coli, 100ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/6622

• Uniprot URL:

  https://www.uniprot.org/uniprot/P37840

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000345

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000336