SHP2 (PTPN11) (NM_002834) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016]

• Synonyms:

  BPTP3; CFC; JMML; METCDS; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2

• Gene ID:

  5781

• UniProt:

  Q06124

• Accession Number mRNA:

  NM_002834

• Chromosomal Location:

  12q24.13

• Expression System:

  E. coli

• Tag:

  N-His

• Related Pathways:

  Adipocytokine signaling pathway, Chronic myeloid leukemia, Epithelial cell signaling in Helicobacter pylori infection, Jak-STAT signaling pathway, Leukocyte transendothelial migration, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Renal cell carcinoma

• Field of Research:

  Adipocytokine signaling pathway, Chronic myeloid leukemia, Epithelial cell signaling in Helicobacter pylori infection, Jak-STAT signaling pathway, Leukocyte transendothelial migration, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Renal cell carcinoma

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Function:

  Druggable Genome, Phosphatase

• Molecular Weight:

  62.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PTPN11

• Species:

  Human

• Protein ID:

  NP_002825

• Overview:

  Purified recombinant protein of PTPN11, Met1-Leu525, expressed in E. coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/5781

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q06124

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_002834

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_002825